The delicate colour harmony that Prosanto Roy achieved through water colour was, was used by him in geometrical, hard-lined figuration with a fine sense of design, both in his paintings of mural dimension and in those of smaller formats. He chose his themes from fairy tales, leading the eyes of the viewers through mysterious mazes of geometrical colour and light areas.

His Schooling began at the age of 13 at the Brahmacharya Ashram in Santiniketan under Rabindranath Tagore, later his schooling in art was taken up by Abanindranath Tagore and Gaganendranath Tagore in their Jorasanko house in Calcutta. Prosanto Roy was Profoundly influenced by the splintered from and cubist treatment of pictorial space and light in the paintings of Gaganendranath.

He became the curator of Kala Bhawan, Santiniketan in 1952 and taught there till his death in 1973.

His first solo show was held in New Delhi in 1951- 52, then Bombay in 1955, Gwalior in 1957 and Lucknow in 1958. In 1971,he exhibited for the last time in Calcutta in 1971.